Mr John Isaac qualified as a doctor in 1982 with an MBBS degree from the University of Singapore and commenced surgical traineeship in 1984. After Qualifying with an FRCS degree form the Royal College of Surgeons, Edinburgh and Glasgow Mr Isaac went on to train in hepatobiliary and liver transplant surgery in Paris, France. On returning to Singapore in 1992, he was appointed as senior lecturer in the surgery department of the University Hospital and was appointed a Consultant Surgeon in 1993 and Associate Professor in 1998. Besides general surgery, he sub-specialised in liver and pancreatic surgery.
In 2004, he was appointed head of the University Department of Surgery, and division of hepato-pancreato-biliary surgery as well as director of liver transplantation, at the National University Hospital in Singapore, positions he held until coming to work in the UK in 2006.
His other interest are laparoscopic (keyhole) surgery and teaching of surgery to undergraduates and post graduate trainees. His research interests are in clinical surgery and basic transplant science as well as development of teaching methodologies. At the Queen Elizabeth Hospital in Birmingham, he is one of a team of consultant surgeons specialising in complex liver, biliary and pancreas surgery and liver transplantation as well as general surgery such as gallbladder disease and hernia surgery.